It’s been ten years since the last wild gathering of the Crazy Ladies, and time has only made them bolder. Menopause has hit—and with it, a whole new level of madness. Their latest mission? Convince Kay, the tough-as-nails, gun-slinging tomboy, to finally say “I do” to Shaun—the same poor guy she once kidnapped to make him answer for the crimes of all men.

But things take a chaotic turn when the five fearless women are lured to a remote motel by a clueless kidnapper who has no idea what he’s gotten himself into. What follows is a weekend of pure pandemonium, as the ladies turn the tables, take charge, and even manage to pair off the hapless criminal with one of their own.